Generalized Deformations and Viscous Dissipation in Lipid Bilayers
- Degree Grantor:
- University of California, Santa Barbara. Physics
- Degree Supervisor:
- Frank L. H. Brown
- Place of Publication:
- [Santa Barbara, Calif.]
- Publisher:
- University of California, Santa Barbara
- Creation Date:
- 2012
- Issued Date:
- 2012
- Topics:
- Chemistry, Physical, Biophysics, General, and Engineering, Chemical
- Keywords:
- Lipid Bilayer,
Neutron Spin-Echo,
Liquid Crystal,
Surface Tension,
Viscosity, and
Membrane - Genres:
- Online resources and Dissertations, Academic
- Dissertation:
- Ph.D.--University of California, Santa Barbara, 2012
- Description:
Though membranes have been studied on micron length scales for some time, much less is known about their behavior within the mesoscopic regime of 1-100 nanometers, which is arguably the most biologically important. My work focuses on the development of theories that bridge these length scales. The research has two main thrusts: I) modeling the effects of viscous dissipation observed in scattering experiments II) describing general types of elastic deformations.
I) Using a previously established hydrodynamic theory, I demonstrated that viscous dissipation within lipid bilayers must be taken into account when analyzing data from neutron spin echo (NSE) spectroscopy measurements. The effects of dissipation were determined across multiple length scales by means of a numerical procedure.
II) I developed a unified model for membrane elasticity that accounts for the effects of bending, compression, molecular orientation, and microscopic noise. By employing a geometric formalism, the theory even allows for a variable number of lipid molecules. The predictions of the model were found to be in excellent agreement with molecular simulations.
- Physical Description:
- 1 online resource (196 pages)
- Format:
- Text
- Collection(s):
- UCSB electronic theses and dissertations
- Other Versions:
- http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:3540272
- ARK:
- ark:/48907/f3w95733
- ISBN:
- 9781267649423
- Catalog System Number:
- 990038916080203776
- Copyright:
- Max Watson, 2012
- Rights:
- In Copyright
- Copyright Holder:
- Max Watson
Access: This item is restricted to on-campus access only. Please check our FAQs or contact UCSB Library staff if you need additional assistance. |