Alexandria Digital Research Library

Accelerating coagulation in traumatic injuries using inorganic nanoparticles

Author:
Kudela, Damien
Degree Grantor:
University of California, Santa Barbara. Chemistry
Degree Supervisor:
Galen D. Stucky
Place of Publication:
[Santa Barbara, Calif.]
Publisher:
University of California, Santa Barbara
Creation Date:
2015
Issued Date:
2015
Topics:
Materials science, Inorganic chemistry, and Medicine
Keywords:
Trauma
Silica nanoparticles
Hemorrhage
Coagulopathy
Polyphosphate
Medicine
Genres:
Online resources and Dissertations, Academic
Dissertation:
Ph.D.--University of California, Santa Barbara, 2015
Description:

Trauma remains the leading cause of mortality between the ages of 1 and 44 in the United States. Uncontrolled blood loss accounts for 50 % of all battlefield deaths and up to 25 % of civilian trauma deaths. This mortality is often the result of a severe clotting impairment known as acute traumatic coagulopathy. Therefore, hemorrhage control remains the a priori goal in the care of the critically injured patient. While great advances have been made in the resuscitation of the injured patient, attenuating bleeding and correction of coagulopathy remain vexing clinical problems. Current clotting treatments are plagued by concerns over excessive cost, poor stability, and safety issues.

In this defense, I present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that mediates the body's natural clotting process. SNPs initiate the blood clotting system's contact pathway, while the endogenous short-chain polyP accelerates the common pathway via rapid formation of thrombin. This enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Because of its low production cost, long-term stability at ambient conditions, and the potential to minimize side effects seen in current treatments, the polyP-SNP therapeutic has the possibility to enable the body to re-establish hemostasis after traumatic injury, preventing massive blood loss and saving lives.

Physical Description:
1 online resource (171 pages)
Format:
Text
Collection(s):
UCSB electronic theses and dissertations
ARK:
ark:/48907/f3w09438
ISBN:
9781339218656
Catalog System Number:
990045865610203776
Rights:
Inc.icon only.dark In Copyright
Copyright Holder:
Damien Kudela
File Description
Access: Public access
Kudela_ucsb_0035D_12711.pdf pdf (Portable Document Format)