Protecting groups play an important role in the process of multistep synthesis of complex molecules due to functional group tolerance. Specific functional groups cannot survive required reagents or chemical environments in the process to synthesis a target molecule so they must be protected to survive the reaction conditions and later be deprotect to their original form. However, protecting a functional group is not ideal because it adds additional steps and material costs to the process. To enhance the efficiency of the synthesis of (+)-Brevisamide, (+)-NPS R-568 and Cinacalcet we kept in mind the concept of being atom economical by avoiding protecting groups.