It is generally hypothesized that there are significant differences in the structural anatomy of the brains of normal people when compared to those who are diagnosed as psychopaths, yet very little quantitative data exists. This research addresses various computer vision and medical imaging applications, mainly focusing on the problem of correlating clinically assigned psychopathic scores (called PCL-R scores) with Magnetic Resonance Imaging (MRI) brain scans of the subjects.

We propose a novel data-driven parts-based regression algorithm for the analysis of such cross-sectional anatomical data. The method helps capture and localize biologically significant parts in the brain exhibiting regression with respect to the associated clinical variable. This analysis is further extended to the case of functional MRI brain scans wherein we present a new multi-modal regression method to capture the correlating anatomical parts between the modalities that are undergoing changes due to the clinical variable. Finally, a formulation of the regression method is provided to learn the complex relationship between each data modality and multiple clinical labels associated with them.