Ion-mobility and computational modeling of biomolecular self-assembly and aggregation
- Degree Grantor:
- University of California, Santa Barbara. Chemistry
- Degree Supervisor:
- Michael T. Bowers
- Place of Publication:
- [Santa Barbara, Calif.]
- Publisher:
- University of California, Santa Barbara
- Creation Date:
- 2015
- Issued Date:
- 2015
- Topics:
- Molecular chemistry and Biochemistry
- Keywords:
- Aggregation,
Amyloid,
Computational modelling,
Ion-mobility mass spectrometry,
Aggregation propensity, and
Self-assembly - Genres:
- Online resources and Dissertations, Academic
- Dissertation:
- Ph.D.--University of California, Santa Barbara, 2015
- Description:
Protein self-assembly leading to fibril formation is an intriguing phenomenon that has been linked to pathological agents in devastating neurodegenerative diseases and has been found to have promising applications in the development of new functional materials. In this dissertation, a combination of ion-mobility mass spectrometry, high level molecular dynamics simulation and microscopy imaging has been employed to investigate the distributions of early oligomers, their conformational transitions in the presence of small-molecule modulators and the structures of toxic and non-toxic oligomers. A variety of biomolecule models was examined to elucidate the driving forces behind amyloid and non-amyloid self-assemblies, and to provide a new approach to aggregation propensity prediction.
- Physical Description:
- 1 online resource (316 pages)
- Format:
- Text
- Collection(s):
- UCSB electronic theses and dissertations
- Other Versions:
- http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:3733564
- ARK:
- ark:/48907/f34m92rb
- ISBN:
- 9781339218687
- Catalog System Number:
- 990045865280203776
- Copyright:
- Thanh Do, 2015
- Rights:
- In Copyright
- Copyright Holder:
- Thanh Do
Access: This item is restricted to on-campus access only. Please check our FAQs or contact UCSB Library staff if you need additional assistance. |