Gold Nanoparticle Characterization : Improved Methods for Measuring Nanoparticle Surface Properties and Colloidal Stability
- Degree Grantor:
- University of California, Santa Barbara. Mechanical Engineering
- Degree Supervisor:
- Sumita Pennathur
- Place of Publication:
- [Santa Barbara, Calif.]
- Publisher:
- University of California, Santa Barbara
- Creation Date:
- 2015
- Issued Date:
- 2015
- Topics:
- Mechanical engineering, Nanoscience, and Nanotechnology
- Keywords:
- Capillary electrophoresis,
Characterization,
Gold nanoparticles,
Gold nanorods,
Stability, and
Microfluidics - Genres:
- Online resources and Dissertations, Academic
- Dissertation:
- Ph.D.--University of California, Santa Barbara, 2015
- Description:
Plasmonic nanoparticles are used in a wide variety of applications over a broad array of fields including medicine, energy, and environmental chemistry. The continued successful development of this class of materials requires the accurate characterization of nanoparticle stability for a variety of solution-based conditions. Although a wide array of methods exist, there is an absence of a unified, quantitative means for complete nanoparticle characterization. This work focuses on the challenges inherent with current methods through a comparative analysis of the current gold standard characterization methods. I propose using capillary electrophoresis and micro-capillary electrophoresis as powerful tools for better quantifying the inherent polydispersity and differences in surface functionalization within a nanoparticle sample. I present the Particle Instability Parameter (PIP) as a robust, quantitative, and generalizable characterization technique based upon UV-Vis absorbance spectroscopy to characterize colloidal instability. I validate PIP performance with both traditional and alternative characterization methods by measuring gold nanorod instability in response to different salt (NaCl) concentrations and as a function of solution pH, salt, and buffer type. I contextualize these methods within the literature on gold nanoparticle characterization to establish a standardized methodology for nanoparticle analysis. Finally, I present a concept for an integrated biodiagnostics platform using gold nanorods based upon an integrated microfluidic microspectrophotometry system for the detection of pathogens.
- Physical Description:
- 1 online resource (153 pages)
- Format:
- Text
- Collection(s):
- UCSB electronic theses and dissertations
- Other Versions:
- http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10011408
- ARK:
- ark:/48907/f33j3chn
- ISBN:
- 9781339472379
- Catalog System Number:
- 990046180090203776
- Copyright:
- Tyler Ray, 2015
- Rights:
In Copyright
- Copyright Holder:
- Tyler Ray
File | Description |
---|---|
Access: Public access | |
Ray_ucsb_0035D_12863.pdf | pdf (Portable Document Format) |
suppInfo.pdf | pdf (Portable Document Format) |