This thesis describes a search for supersymmetry (SUSY) at the Large Hadron Collider using data collected in Run 2011 at center of mass energy of 7 TeV by the Compact Muon Solenoid detector with an integrated luminosity of 4.98 fb-1. First, the Large Hadron Collider is briefly described along with the Compact Muon Solenoid detector. Second, the Standard Model of particle physics is described which leads to the motivations for supersymmetry and its description. Finally, a search for supersymmetry in events with a single lepton, 2 b-tagged jets and missing transverse energy is documented in detail. The results are used to predict the yields from the standard model in bins missing transverse energy ( / ET ) and total transverse hadronic energy (HT). Limits are set using these results using a minimal supergravity SUSY model and simplified model spectra SUSY model.